Characterization of the Interaction between Interleukin-13 and Interleukin-13 Receptors

Mutants of interleukin 13 with altered reactivity toward interleukin 13 receptors.

Interleukin 13 (IL13) belongs to a family of cytokines whose members exhibit structural homology, despite amino acid sequence dissimilarity. For example, while of limited sequence homology, IL13 and IL4 share a signaling receptor, IL13/4 receptor, on a variety of human normal cells. However, a subclass of IL4-independent IL13 receptors is overexpressed on certain transformed cells, including hu...

The association of interleukin-13 gene polymorphism withkala-azar patients

Background& Objective: Host resistance towards Leishmania infection is mediated by cellular immune responses leading to macrophage activation and parasite killing. According to the important role of IL-13 in the defense against visceral leishmaniasis (VL) and the known effect of the IL-13 gene polymorphisms on its production, the aim of this study was to investigate the probable relationship be...

Wrestlers’ immune cells produce higher interleukin-6 and lower interleukin-12 and interleukin-13 in response toin vitro mitogen activation

Objective(s):Although recent investigations have shown chronic inflammation and inflammation-associated diseases might be ameliorated by exercise; little is known about the relation between exercise training with anti/pro-inflammatory cytokines. Materials and Methods: This cross sectional study was conducted to compare interleukin-4 (IL-4), IL-6, IL-10, IL-12, IL-13, interferon gamma (IFN-γ) le...

Characterization of the Cytoplasmic Domain of Interleukin-13 Receptor-a*

Interleukin (IL)-13 and IL-4 are pleiotropic immunoregulatory cytokines that share many overlapping biological properties reflecting the fact that both can utilize a receptor complex composed of the IL-4 receptor-a (IL-4Ra) chain and the IL-13Ra chain. The cytoplasmic domain of the IL-13Ra is 60 amino acids long and is essential for IL-13-dependent growth. It contains a Prorich domain in the me...

Effects of Interleukin-4 and Interleukin-13 on Bone